SOD1 and ulcer disease: It has been demonstrated beyond a reasonable doubt that oxidative stress and inflammation play a significant part in the etiology of indomethacin-induced injury to the stomach.86,87 In the current study, the level of antioxidant enzymes (SOD and GPX) was found to be considerably lower in the group that was subjected to ulcer induction (G2) compared to the group that served as the control (G1) and the other treatment groups (G3, G4).