CD8A and mitochondrial DNA depletion syndrome 4a: In comparison, patients with advanced HIV disease (AHD) had CD4+, CD8 + T cells counts, CD4/CD8 ratio, and viral load for the patients with AHD were 110.24 ± 62.77 cells/μl, 790.83 ± 559.02 cells/μl, 0.19 ± 0.13, and 3.16 ± 8.40 × 105 copies/ml, respectively (Table 1).