Subsequent research delved deeper into lipid metabolites within the human bloodstream, indicating that heightened levels of total cholesterol and total lipids could potentially disrupt circadian rhythms, resulting in increased glucose, insulin, and triglyceride concentrations, hastened lipid storage, and ultimately contributing to the onset of obesity, muscle atrophy, reduced physical activity levels, and heightened susceptibility to frailty (53). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.