An inverse relationship between C-reactive protein (CRP) and bilirubin concentration was also found in the serum of patients with diabetes and the inverse relationship between bilirubin and proinflammatory cytokines in serum (tumor necrosis factor-α, interleukin-6, visfatin, resistin - human model; monocyte chemoattractant protein-1 and leptin - animal model) and a positive relationship between bilirubin and adiponectin in humans with obesity (56-58). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.