Male mice did not exhibit significant effects related to anxiety in the EPM, but molecular analysis showed up-regulation of estrogen receptor 2 (ESR2; 20 and 200 μg/kg/day groups) and dopamine receptor 1 (20 μg/kg/day and 750 mg/kg/day groups) in the amygdala but not in the hippocampus. This evidence concerns the gene ESR2 and Anxiety.