NR3C1 and Anxiety: In addition, when rats were orally administered BPA (40 mg/kg/d) during pregnancy and lactation, their female offspring at PND 40–50 developed an anxiety-like phenotype, characterized by hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, impaired glucocorticoid receptor (GR)-mediated negative feedback regulation of the HPA axis, altered hippocampal synaptic plasticity, and increased anxiety-like behaviors associated with a reduction in the expression of metabotropic glutamate 2/3 receptors (mGlu2/3 receptors) in the hippocampus (27).