MECP2 and atrial fibrillation: Moreover, clinical evidence has shown that classical RAS inhibitors (ACE-Is and ARBs) can reduce the incidence Additionally, MECP2 regulation of transcription of neuronal ligands, condensation of prometaphase chromosomes, and receptor-mediated mitophagy may play a role in the onset of atrial fibrillation induced by hyperuricemia, but the specific mechanisms remain unknown and require further investigation.