A follow-up study of 4,570 DKD patients over three years found that individuals with a urine albumin-to-creatinine ratio (UACR) change of ≥30% had a significantly higher risk of adverse renal outcomes, such as serum creatinine doubling or the need for renal replacement therapy, compared to those with stable UACR and estimated glomerular filtration rate (eGFR) levels (26). The gene discussed is ALB; the disease is diabetic kidney disease.