Aberrant regulation of MAPK8 has garnered attention as a contributing factor in a myriad of pathological conditions, encompassing diabetes mellitus, oncogenesis, autoimmune disorders, cardiac hypertrophy, and asthmatic phenotypes, thereby underscoring its pivotal role in maintaining cellular homeostasis and disease pathogenesis (49, 50). The gene discussed is MAPK8; the disease is cardiac hypertrophy.