Melanoma–astrocytoma syndrome (MAS) is a rare autosomal dominant tumor–predisposition syndrome linked to germline mutations in the CDKN2A gene, characterized by an increased risk of multiple tumors, including cutaneous melanoma, astrocytoma, nerve sheath tumors, pancreatic cancer, and squamous cell carcinoma of the oropharynx [29]. The gene discussed is CDKN2A; the disease is familial pancreatic carcinoma.