Regarding the expression of miR-223-3p, isodrimeninol showed a significant increase in the expression of this miRNA at the 12.5 μg/ml concentration in both cultures, considering that the increased expression of miR-223-3p decreases the expression of NLRP3, which is a key mediator in the production of IL-1 family cytokines in periodontitis (46, 47). This evidence concerns the gene NLRP3 and periodontitis.