Since the start of the study, mutations in four additional genes (MYOF, HS3ST6, CPN1, and DAB2IP) and additional variants in F12 and ANGPT1 genes have been reported to be associated with HAE-nC1INH (5, 8, 9); however, patients were not screened for those mutations in CASPIAN. The gene discussed is HS3ST6; the disease is hereditary angioedema.