It has been observed that TNF-α in the synovial tissue of RA patients inhibits FOXP3 phosphorylation, impedes the proliferation of Tregs, and reduces the secretion of the functional IL-10 and TGF-β (37, 38), which plays crucial roles in the activity and severity of RA (39). The gene discussed is FOXP3; the disease is rheumatoid arthritis.