PRF1 and neoplasm: Therefore, the anti-PSMA antibody (Ab), redirects NK cells (including innate and adoptive NK cells) to target PCa cells through the tumor-specific target molecule PSMA on the one hand, and to CD16-positive NK cells on the other hand, forming cytolytic synapses and activating NK cells to release cytotoxic granules containing perforin and granzymes to directly lyse PCa cells and cytokines to recruit other immune cells to the tumor site (20).