POU4F1 and colon adenocarcinoma: developed a risk prediction model based on disulfidptosis-related genes (DRGs) in colon adenocarcinoma patients, demonstrating that POU4F1 knockdown (a DRG) markedly attenuated COAD cell proliferation, migration, and disulfidptosis susceptibility while augmenting cellular senescence (55, 56).Notably, hepatocellular carcinoma (HCC) patients with elevated disulfidptosis activity exhibited enhanced therapeutic responsiveness to PD-1/PD-L1 blockades (55, 56).