TNFSF4 and inflammatory bowel disease: Furthermore, in a genetic association study cohort comprised of 474 IBD patients with European ancestry, two loci were found to be significantly associated with response to TNFi and were replicated with a p <1 x 10–03 in a validation cohort: rs116724455 in TNFSF4/18 and rs2228416 in PLIN2. Allele C of rs116724455, located on chromosome 1 near the TNFSF4 and TNFSF18 genes, was strongly associated with nonresponse to TNFi (OR = 19.9, p = 4.79×10−8).