A meta-analysis, focused on spondyloarthropathy, psoriasis and Crohn’s disease, identified that the G allele in TNF -238G>A (rs361525), TNF -308G>A (rs1800629) and the C allele in TNF -857C>T(rs1799724) showed better response to TNFα blockers in the European population, but failed to show a significant impact in the Asian population (119, 144). The gene discussed is TNF; the disease is Crohn disease.