In hepatocellular carcinoma (HCC), OTUB2, OTUD3, and OTUD5 stabilized the expression of PJA1 (28), ACTN4 (29), and SLC38A1 (30) by deubiquitination, respectively, which facilitated the proliferation and metastasis of HCC. This evidence concerns the gene ACTN4 and hepatocellular carcinoma.