In this study, we found that the m6A-reading protein IGF2BP2 increases the stability and translation of HIF1α mRNA transcripts by targeting the recognition of m6A, which in turn promotes the activity of enzymes related to glucose metabolism, inhibits mitochondrial oxidative phosphorylation, reduces the generation of ROS, and ultimately promotes glucose metabolism and radiotherapy resistance in gastric cancer. The gene discussed is IGF2BP2; the disease is gastric cancer.