To address these limitations, we here developed a xenograft model system of RMS in embryonic zebrafish making use of its transparency, the flk1::GFP background to visualize endothelial cells, using a high-throughput scanning microscope to assess tumour-stromal interactions with focus on angiogenesis and the initial stages of drug response to MRTKI that are impossible or challenging to study in other preclinical contexts such as in vivo in mice. This evidence concerns the gene KDR and neoplasm.