These two subtypes also broadly subdivide by molecular drivers, with 80% of ARMS associated with chromosomal translocations t(2;13)(q35;q14) or t(1;13)(p36;q14), leading to the formation of a fusion of PAX3 or PAX7 with FOXO1 (1, 2, 5). Here, FOXO1 is linked to alveolar rhabdomyosarcoma.