Additionally, Bifidobacterium can reduce the presence of immunosuppressive cells in the tumor microenvironment, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and decrease the secretion of inhibitory cytokines such as IL-10 and TGF-β, thereby alleviating the immune suppressive state and enhancing anti-tumor immune responses (67). This evidence concerns the gene IL10 and neoplasm.