TGFB1 and cancer: Recently, another group performed unbiased analysis for regulators of the TME using spatial functional genomics and found that the Tgfbr2 knockout in cancer cells could increase TGFβ bioavailability, drive TGFβ-mediated CAF activation, and convert the TME to a fibro-mucinous state inducing T-cell exclusion and ICB resistance (43).