The specific receptor of IL-15 (IL-15Rα) is secreted primarily by NK, T, and B cells (101).Binding of IL-15R to IL-15Rα produces the IL-15R/IL-15Rα complex, which binds to the IL-2Rβγ (IL-15Rβγ) expressed by effector cells (NK, T, and B cells), and further activates them to kill tumor cells (102). Here, IL15 is linked to neoplasm.