IL-21-armed OVV VΔTK-STCΔN1L-IL-21 was injected into subcutaneous, orthotopic and disseminated mouse models of pancreatic cancer, and phosphoinositide 3-kinase δ (PI3Kδ) inhibitor CAL-101 was used to inhibit the virus uptake by macrophages. Here, IL21 is linked to familial pancreatic carcinoma.