In addition, IL-12 can induce Th1 differentiation, reducing the expansion of immunosuppressive cells such as tumor-associated macrophages and myeloid-derived suppressor cells (MDSCs) (88–90).Furthermore, IL-12 promotes the production of more IFN-γ by CD8+ T cells, exerting its inhibitory effect on tumors. Here, CD8A is linked to neoplasm.