IL-10 promotes tumor growth and metastasis in many ways, including downregulation of antigen-presenting cells and major histocompatibility complex (MHC) expression in tumors to reduce antigen presentation (32, 71),promote naive CD4+ T cells to Th2 cells (72), and encourage the loss of E-calmodulin and increase of N-calmodulin (73), thus promoting tumor growth. Here, HLA-C is linked to neoplasm.