CD177 and neoplasm: Moreover, it offers genetic stability, rapid iteration with mature progeny produced in 6–8 h, a wide range of infectious forms, a variety of infected tumor cells, no need for a specific cell-surface receptor, great viability, and excellent clinical safety (20–26).OVVs can also directly lyse tumor cells, cause vascular damage, counteract the immune suppressive effects of the TME, and increase the infiltration of lymphocytes in the tumors.