SMAD2 and hepatocellular carcinoma: High levels of miR-155 have been reported in HCV-infected patients.12 MiR-125 is positively associated with APC and plays a role in preventing hepatocarcinogenesis.13 MiR-125b inhibits EMT by targeting SMAD2-4.14 Studies by Gougelet et al.15 and Zhu et al.16 have shown that miR-34 is regulated by β-catenin and plays an important role in HCC.