Notable, GLY has shown estrogenic properties and the ability to induce the proliferation of estrogen-dependent MCF-7 human BC cells (Thongprakaisang et al., 2013; Mesnage and Antoniou, 2017) and ERalpha (ESR1)-positive cholangiocarcinoma cells (Sritana et al., 2018). This evidence concerns the gene ESR1 and breast cancer.