In sarcopenic congestive heart failure patients, serum Hp 1–1 phenotype significantly correlates with appendicular skeletal muscle index (ASMI) but not hand grip strength, while Hp 2–1 and −2 phenotype negatively associates with ASMI and hand grip strength [32], indicating potential prognostic value of the Hp2 isoform for cachexia. This evidence concerns the gene HP and congestive heart failure.