NFKB1 and rheumatoid arthritis: Active Notch signaling has been observed in various inflammatory conditions such as rheumatoid arthritis, cancer, PRRS, IBD, the Influenza virus H1N1, Echinococcus, the respiratory syncytial virus, Japanese encephalitis virus, Mycobacterium bovis BCG, tuberculin, Ehrlichia chaffeensis, and LPS, through its association with and activation of Toll-like receptors, NF-κB, and MAPK pathways [30,32–34].