To investigate the potential effects of elevating YAP1 expression in the hippocampi of the SAMP8 mouse model of AD, we stereotactically injected AAVs expressing full-length mouse YAP1 (AAV-YAP1) with the hSyn promoter into the hippocampi of 3-month-old male SAMP8 and SAMR1 mice (Fig. 4a). The gene discussed is RIC8B; the disease is Alzheimer disease.