MAPK8 and amyloidosis: Indeed, we observed in the hippocampi of dKI mice a significant increase in NOX1 and phosphorylated JNK/SAPK/total JNK at 6 months (Fig. 7L-N, Fig.S6D, E), while CDK5 was significantly increased by 12 months (Fig. 7L, O, Fig.S6D, E), suggesting that the UNC5C T835M-mediated apoptotic pathway was exacerbated by amyloid pathology in dKI mice.