UNC5C and hippocampal atrophy: Polyphen-2 showed that the T835M substitution was “possibly damaging” to UNC5C protein structure with a score of 0.929 out of 1.0 (a mutation with a score of 0.0 is “tolerated” while that with 1.0 is “deleterious”; Fig. S4A), suggesting potential functional consequences that may explain the previously reported findings [1] and our own results of hippocampal atrophy suggesting neurodegeneration, as the mutation is in/near the hinge region and could affect the UNC5C open/closed state that triggers cell death or growth activities.