TARDBP and behavioral variant of frontotemporal dementia: Furthermore, phosphorylated TDP-43 aggregation in a cohort of FTLD-TDP autopsy cases with bvFTD (n = 39) was also reported to spread sequentially from the site of initiation (orbital gyri, gyrus rectus, and amygdala) to connected brain regions as disease pathology progresses [89], further supporting a prion-like propagation mechanism of TDP-43 pathology.