This is the first report of a patient-derived heterotypic amyloid filament for TDP-43, and it raises the question whether TDP-43 could also co-assemble with the LCD of other ALS-linked RBPs – such as hnRNPA1 or hnRNPA2B1 which have been shown to co-localize with pathological TDP-43 inclusions in patients that carry mutations in the corresponding genes [47]. This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.