Matrin 3 has been identified as a component of neuronal cytoplasmic inclusions in motor neurons of a number of sporadic ALS cases [109] and cases with C9ORF72 mutations [48, 110], although more research is needed to unambiguously confirm Matrin-3 aggregation as a pathological feature of ALS [111, 112]. Here, MATR3 is linked to amyotrophic lateral sclerosis.