TARDBP and amyotrophic lateral sclerosis: In line with this, earlier studies indirectly evaluated the conformation of aggregated TDP-43 in different brain regions and spinal cord of ALS and FTLD-TDP by immunoblotting protease-resistant TDP-43 fragments from detergent-insoluble homogenates: distinct banding patterns of TDP-43 fragments were observed in different disease subtypes (presumably reflecting pathological TDP-43 species with different structures, also referred to as “strains”), while banding patterns were identical across multiple CNS regions in individual patients [320].