TARDBP and amyotrophic lateral sclerosis: This is supported by a wealth of research relying on RNA sequencing efforts performed in human and mouse systems upon TDP-43 depletion including cultured cells with genetic silencing of TDP-43 (such as human iPSC-derived neurons [182, 183], neuron-like SH-SY5Y cells [184, 185] and non-neuronal cell lines [186]; mouse primary neurons [187], neuron-like and muscle cell lines [188]), sorted neuronal nuclei with TDP-43 nuclear clearance isolated from post-mortem human ALS-FTD brains [189], or mouse brain tissue following antisense oligonucleotide (ASO)-mediated TDP-43 knockdown [178].