TARDBP and amyotrophic lateral sclerosis: Interestingly, recent immunohistochemical examination of 368 autopsy cases reported co-pathology of annexin A11 and TDP-43 in all sporadic FTLD-TDP type C cases – as well as a small proportion (3–6%) of FTLD-TDP type A-B, ALS and LATE cases – suggesting that combined pathology of annexin A11 and TDP-43 also occurs in the absence of ANXA11 mutations [114].