Furthermore, TDP-43 aggregates in ALS display significant morphological heterogeneity, and a recent investigation of post-mortem brain autopsies from 61 ALS cases (without FTD) proposed that ALS-TDP can be further classified in three histopathological subtypes – denoted as ALS-TDP type E, type B and type SC (scarce cortical) – based on the morphology, abundance and composition (i.e. colocalization with p62) of phosphorylated TDP-43 pathology in the motor cortex [75]. Here, TARDBP is linked to amyotrophic lateral sclerosis.