Unexpectedly, this revealed that the ALS-associated RBP annexin A11 (ANXA11) co-assembles with TDP-43 in heteromeric FTLD-TDP type C amyloid filaments, whereby the ordered filament core is composed of defined regions from the LCDs of TDP-43 and ANXA11 respectively [86]. The gene discussed is ANXA11; the disease is amyotrophic lateral sclerosis.