TARDBP and amyotrophic lateral sclerosis: Cytoplasmic TDP-43 condensates or aggregates can sequester components of the nuclear pore complex and nucleocytoplasmic transport machinery in cultured cell lines and neurons, mutant TDP-43 transgenic mice, and ALS-FTD postmortem CNS tissue [254, 391–396], which in turn could trigger deficits in nuclear transport of proteins such as TDP-43 itself.