Furthermore, progranulin-deficient microglia (in which the FTD gene GRN has been genetically deleted) were reported to directly promote the formation of cytoplasmic TDP-43 granules, along with nuclear pore defects and cell death, in cultured cortical neurons by secretion of complement factors in the extracellular medium [346]. The gene discussed is TARDBP; the disease is frontotemporal dementia.