In the brain, ABCA1 lipidates ApoE [120], facilitating Aβ clearance [121, 122], regulating peripheral vasculature and blood-brain barrier integrity, as well as anti-inflammatory signaling [123], influencing myelination, synaptogenesis, and neurotransmission [124], playing a crucial role in the onset and progression of AD. This evidence concerns the gene ABCA1 and Alzheimer disease.