In line with the accumulation of γH2AX signal, increased levels of the other DNA damage sensors such as 53BP1, and phospho-Ser1981 ATM (p-ATM) have also been reported [6, 79, 80, 91], although total levels of ATM and MRN proteins seem reduced in AD cortical neurons, which could further contribute to the accumulation of DNA damage [92, 93]. This evidence concerns the gene TP53BP1 and Alzheimer disease.