GPR43 alleviates concurrent neuronal, mitochondrial, and synaptic dysfunction in AD mice, a crucial aspect of AD pathophysiology (Bindels et al. 2013; Qin et al. 2022; Mitchell et al. 2013; Finkel and Holbrook 2000; Verdin et al. 2010; Nakamura and Lipton 2010; Lee et al. 2004; Koffie et al. 2011). The gene discussed is FFAR2; the disease is Alzheimer disease.