Western blot analyses revealed significant upregulation of both PSD-95 (0.49 ± 0.10 vs. 0.22 ± 0.04 in AD, p < 0.05) and SYP (0.61 ± 0.04 vs. 0.34 ± 0.08 in AD; p < 0.05) in the whole brain lysates from GPR43-overexpressing (GPR43-OE) mice compared to AD littermates (Fig. 4A and B). Here, SYP is linked to Alzheimer disease.