Flow cytometry analysis revealed a 3.0-fold increase in apoptotic cells in GPR43-depleted AD models (50.13 ± 5.29% in AD/Si-GPR43 vs. 15.07 ± 0.51% in AD; p < 0.05; Fig. 7I), collectively demonstrating that GPR43 suppression exacerbates apoptotic vulnerability in Aβ1–42-challenged hippocampal neurons. The gene discussed is FFAR2; the disease is Alzheimer disease.