NOD2, as a key gene involved in inflammatory responses and regulating autophagy(Fritz et al. 2011; Mukherjee et al. 2019; Negroni et al. 2018), was the first susceptibility gene identified in association with inflammatory bowel disease(Branquinho et al. 2016; Goethel et al. 2019; Venkataraman and Rivas 2019). This evidence concerns the gene NOD2 and inflammatory bowel disease.