Based on increasing research demonstrating the therapeutic effects of targeting NOD2 and autophagy in inflammation and CRC, this study for the first time investigated the efficacy of low concentrations of DEH in inhibiting IBD inflammation by suppressing NOD2, and high concentrations of DEH were found to promote NOD2-induced cell autophagy, exhibiting significant anti-CRC effects. This evidence concerns the gene NOD2 and inflammatory bowel disease.