For example, disruption of the CARMA1–BCL10–MALT1 (CBM) complex via deletion of one Carma1 allele induces an IFN-γ+ fragile Treg cell phenotype, which improves overall tumor control and sensitizes tumors to ICB [186], thereby demonstrating a mechanism to modify TCR–PKC signaling and “rewire” Treg cell function. This evidence concerns the gene CARD11 and neoplasm.