BRCA1 and breast cancer: Although survival (i.e. percentage of people alive at selected time-points after diagnosis) in PHTS patients with BC was no worse than in sporadic BC patients, BC mortality (i.e. number of deaths from BC in the PHTS population) and overall mortality (i.e. number of deaths from any cause in the PHTS population) in female PHTS patients was increased compared to the general population (SMRca = 3.7, 95%CI = 2.6–5.0), and was to an extent comparable to that in female BRCA1/2 patients (SMRca = 3.2, 96%CI 2.0–5.3) [24].