We found Tgm2 silencing led to a significant increase in the CD206-CD11c+ population along with a significant decrease in the CD206+ CD11c- population, a recently identified plastic macrophage subset associated with IR in humans56,67, suggesting that release of TGM2 by ATMs contributes to the modulation of inflammatory ATMs plasticity in obesity. This evidence concerns the gene MRC1 and obesity due to melanocortin 4 receptor deficiency.