HSPB8 and cardiomyopathy: Until now, missense and frameshift HSPB8 mutations have been associated with hereditary (mostly motor) neuropathies, neuromyopathy, and pure myopathy, mainly of adult-onset [8, 9, 11, 15], but not with cardiomyopathy, suggesting that the novel frameshift mutations may display other mechanisms of pathogenicity that affect various striated muscles.