Similar to our observation regarding cholesterol biosynthesis and retinoic acid activity, a report by Muchenditsi et al.45 on gene expression in ATP7B deficient mice showing the Wilson disease phenotype with increased Cu accumulation found that cholesterol biosynthesis and liver X receptor/retinoid X receptor (LXR/RXR) activation were downregulated and upregulated, respectively. Here, ATP7B is linked to Wilson disease.