We extended our exploration of gene expression patterns related to neuronal subtype vulnerability by performing pathway analyses of differentially expressed genes with a categorical contrast for diagnosis (AD or non-diseased control) or by regression for relative levels of tissue 4G8+ β-amyloid or PHF1+ pTau immunostaining52 (Fig. S10b; Supplementary Data file 3). The gene discussed is PHF1; the disease is Alzheimer disease.