Moreover, articles in NSCLC and GBM differentiated cells showed that TTFields alone induce replicative stress by decreasing the expression of protein from the DNA replication complex genes MCM6, MCM10 (Mini-Chromosome Maintenance proteins) and FANC, leading to the instauration of a vulnerability environment sensitizing cells to IR and to the formation of Double-Strand Breaks (DSB) [15, 16, 24]. This evidence concerns the gene MCM6 and glioblastoma.