In some gliomas, oncogenic FGFR3-TACC3 (Transforming Acidic Coiled-Coil containing proteins) or FGFR1-TACC1 fusions cause constitutive FGFR3 or FGFR1 activation, promoting tumour growth [44, 45]. The gene discussed is FGFR1; the disease is central nervous system cancer.