A human TRAV35+/TRBV10-2+ CD4+ T cell clone was previously isolated from the PBMC of a HLA-DRB1∗04:01 patient with ACPA-positive RA, via HLA-DRB1∗04:01-TNC1014,1016cit tetramer (29) (Fig. 2A). The gene discussed is PRTN3; the disease is rheumatoid arthritis.