Prior studies demonstrate this regulatory axis in cancer biology: circFOXP1 was shown to bind PTBP1, stabilizing PKLR mRNA to enhance the Warburg effect in GBC,28 while circ_0021727 recruits EIF4A3 to stabilize GBX2 mRNA, driving angiogenesis in esophageal squamous carcinoma.29 This evidence concerns the gene PKLR and cancer.