Cohen et al. in an RCT with a 2-year follow-up, including a total of 100 patients with T2DM, obesity (BMI of 30–35 [calculated as weight in kilograms divided by height in meters squared]), and chronic kidney disease (CKD) stages G1 to G3 and A2 to A3 (early stage—urinary albumin-to-creatinine ratio [uACR] >30 mg/g and estimated glomerular filtration rate >30 mL/min). Here, ALB is linked to obesity due to melanocortin 4 receptor deficiency.