NFKB1 and diabetes mellitus: In the context of inflammation, HSP72 is produced in the intracellular environment in response to stressful situations, and has an anti-inflammatory effect, blocking the activation of the main nuclear transcription factor related to inflammation, the nuclear factorkappaB (NF-κB).11,12 However, in conditions of chronic inflammation and insulin resistance, such as diabetes, the ability of cells to activate the HSR is compromised, causing cellular dysfunction, perpetuation of inflammation, and increased risk of complications in diabetes.13