Additionally, this study proposes that during (1) early infection, the TrAP protein (AC2) establishes virus infection by inhibiting host PTGS, and (2) the NSP becomes the main pathogenic determinant at the late stage of infection (SACMV DNA-A and SACMV-B replicate in the nucleus) by suppressing PTI responses (Fig 5a). The gene discussed is ADCY2; the disease is viral infectious disease.