TFEB and viral infectious disease: Furthermore, TFEB protein was substantially preserved during viral infection when cotreated with inhibitors of ubiquitin-proteasome system (UPS), including carfilzomib (CFZ; proteasome inhibitor), TAK-243 (ubiquitin E1 inhibitor), and MLN4924 (NEDD8 E1 inhibitor) (Fig. 1, F to H).