CD40 and Alzheimer disease: ADAM10 (a neuronal α‐secretase that proteolytically processes amyloid precursor protein [APP] along the non‐amyloidogenic pathway, generating neuroprotective fragments and mitigating Aβ plaque formation32) and CD40 (which plays an essential role in amyloid‐beta‐induced microglial activation33) were increased in AD brain neurons as well.