The most significantly upregulated proteins in AD neurons were neprilysin (NEP), CD163, ADAM10, CD11c, CD40, lysosome‐associated membrane protein 2A (LAMP2A) glucocerebrosidase (GBA), and CD11b, and anticipated phosphorylated tau (S214 and S396) (labeled in Figure 2A). This evidence concerns the gene GBA1 and Alzheimer disease.