APOE and Alzheimer disease: Traditional hypothesis‐driven research focused on specific proteins has yielded valuable insights identifying amyloid beta (Aβ) as the primary component of plaques,5 tau protein as the core constituent of NFTs,6 and apolipoprotein E (APOE) as the most significant genetic risk factor for late‐onset AD,7, 8 but it has limitations in comprehensively understanding the complex AD proteome.