RXRG and neoplasm: However, analysis of the larger TCGA cohort revealed statistically significant correlations between high RXRG expression and several aggressive clinicopathological features: increase in tumor size (P = 0.011), presence of LNM (P = 0.041), advanced clinical stage (P = 0.035), specific histological subtypes (P = 0.008), and BRAFV600E mutation status (P < 0.001) (Table 1).