Enrichment analyses with the mutated genes showed involved key processes for cancer progression such as Notch signaling, TGFß signaling, and again p53 activity regulation (Fig. 3C) (Table S6) and the alteration of transcription factors related to epigenetic mechanisms including Polycomb (EZH2, SUZ12) (Fig. 3D) (Table S7). The gene discussed is TP53; the disease is cancer.