CNTN6 and amyotrophic lateral sclerosis: Shared genetic loci, such as CNTN6, encoding an axon structural protein, and GLT8D1, encoding a glycosyltransferase enzyme, indicate shared genetic risk between ALS and schizophrenia.14,15 Increased prevalence of schizophrenia and suicidal behavior among ALS kindreds suggests on the other hand that the pathogenic processes contributing to ALS might also contribute to the development of psychiatric disorders.16