Additionally, the increase in spleen weight due to EAU was greater in the RAMP2 (±) mice than in the RAMP2 (+/+) mice, similar to the findings in AM (±) mice (Fig. 3E), suggesting that the AM-RAMP2 system plays a role in the inflammatory response and the splenomegaly caused by EAU. This evidence concerns the gene RAMP2 and Splenomegaly.